A/P Rosa, in collaboration with a team of experts, has co-authored two recently published papers in Dental Materials that provide essential guidance for researchers studying biomaterials for dental applications. These works address key aspects of biocompatibility and dental pulp tissue engineering, offering practical recommendations and methodological insights to advance research and clinical practice. Both papers are freely available in Dental Materials.
The first paper, Guidance on the assessment of biocompatibility of biomaterials: Fundamentals and testing considerations, focuses on the critical importance of biocompatibility in ensuring patient safety and material functionality. It outlines strategies for assessing biocompatibility, emphasizing the selection of appropriate tests, cell types, and parameters based on the material's intended application. The paper also highlights the significance of thoroughly characterizing the material’s composition and properties to better interpret test outcomes and identify potential cytotoxic factors. By advocating for precise reporting of methodologies and results, the authors aim to enhance research reproducibility and improve communication with the scientific community, regulatory bodies, and healthcare providers.
The second paper, Guidance for evaluating biomaterials’ properties and biological potential for dental pulp tissue engineering and regeneration research, delves into the challenges and opportunities in the field of dental pulp regeneration. This complex area requires biomaterials capable of supporting functions such as immune defense, vascularization, and reparative dentinogenesis. The paper explores the biological foundations of pulp tissue engineering, offering recommendations for evaluating biomaterials’ properties, such as surface characteristics, degradation rates, and mechanical strength. It provides guidance on designing research protocols to study how biomaterials influence cellular behavior and tissue outcomes, with the goal of advancing effective regeneration strategies.
These papers, developed through collaboration with leading experts in the field, aim to establish robust standards and recommendations for researchers. By addressing both fundamental principles and practical methodologies, they serve as valuable resources for designing and reporting studies in biomaterials research, ultimately supporting progress in biocompatibility assessment and dental pulp regeneration.
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